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OCR: Hfr is an acronym for high fre quency recombination. In Hfr strains, a fertility factor is integrated into the bacterial chromosome. Because of the transfer properties of the fertility factor, Hfr strains can efficiently transmit chromosomal genes to F-recipients. Chromosomal transfer begins at a specific point within the fertility factor and proceeds in one direction. While a single strand is being transferred by the donor, a complementary strand is synthesized in the recipient. In principle, an Hfr strain can transfer its entire chromosome to an F-recipient. Recombination in the recipient causes genes of the Hfr donor to be stably incorporated into the F-recipient